The hypoglycemic action of Glimepiride may be potentiated by certain drugs, include NSAIDs and other drugs that are highly protein bound such as salicylates, sulfonamides, chloramphenicol, coumarin derivatives, probenecid, monoamine oxidase inhibitors, and beta adrenergic blocking agents. Thiazides and other diuretics, corticosteroids, phenothiazines, estrogens, oral contraceptives, nicotinic acid, sympathomimetics, thyroid hormones and isoniazid tend to reduce the hypoglycemic effect of glimepiride, when administered with it.
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